News

News are coming concerning the newt GP2A meeting in Nottingham….

 

it will take place on 20-23 Aug 2019…

 

more to come…

Social Event

Conference dinner

The GP2A-JFB 2018 conference, organized by Prof. Patrick Dallemagne – Univ. Caen, Prof. Thierry Besson – Univ. Rouen and Prof. Christophe Rochais – Univ. Caen took place in Asnelles sur Mer (Normandy – F) from 13th to 15th June 2018.

Welcome

   
Prof. Raphaël Frédérick
University of Louvain (B)
JFB grouping
Prof. Pascal Marchand
University of Nantes (F)
Chair of GP2A
   
Welcome slide Welcome Team

Plenary lectures

     
Dr Louisa Barré – CEA
University of Caen (F)
Dr Thomas Cailly
University of Caen (F)
Dr Corinne Fruit
University of Rouen (F)
 
Prof. Raphaël Frédérick
University of Louvain (B)
Dr Niamh O’Boyle
University of of Dublin (IRL)
Dr Tatiana Besset
University of Rouen (F)
   
Prof. Maria Laura Bolognesi
University of Bologna (I)
Prof. Maria-João R. P. Queiroz
University of Minho, Braga (P)
Prof. Pascal Bonnet
University of Orléans (F)
     
Dr Shailesh Mistry
University of Nottingham (UK)
Prof. A. Ganesan
University of East Anglia, Norwich (UK)
Dr Cédric Logé
University of Nantes (F)
   
Prof. Johan Van der Eycken
University of Ghent (B)
Prof. Anne-Sophie Voisin-Chiret
University of Caen (F)

Early career researchers’ showcases

Dr Jade Fogha – ICOA
University of Orléans (F)
Dr Clément Fontenelle – LCMT
University of Caen (F)
Dr Marta Abellán-Flos ICMMO
University of Orsay (F)
Dr Charles Skarbek – ICMMO
University of Orsay (F)
Dr Julien Diharce – ICOA
University of Orléans (F)

Flash presentations of posters (PhD students)

   
Thomas Dal Maso
University of Namur (B)
Pauline Zipfel
University of Caen (F)
Yvain Gérard
University Clermont Auvergne (F)
     
Irène Pachon
University of Besançon (F)
Windbedema Ouedraogo
University of Caen (F)
Pauline Loupias
University of Picardie (F)
   
Sangheeta-Laura Thirumaran
University of Caen (F)
Fanny Danton
University Le Havre Normandie (F)
Viet Hung Dao
University of Nantes (F)
     
Reynald Mangeant
University of Caen (F)
Amanda Garrido
University of Tours (F)
Caroline Lanthier
University of Caen (F)
   
Gilles Degotte
University of Liège (B)
Agnieszka Zak
University of Orléans (F)
Bérénice Hatat
University of Caen & Montpellier (F)
     
Léo Faïon
University of Lille (F)
Martina de Pascale
University of Caen (F)
Alice Ameryckx
University of Louvain (B)
 
Christina Picken
University College London (UK)

Best Oral Presentations

Reynald Mangeant, University of Caen – France: Fluorinated indazole derivatives: promising structures for 5-HT4 receptors PET radiotracers
Dr Jade Fogha, University of Orléans – France: Crystallization additives, not so useless in in-silico kinase research

Best Posters

Florence Couly, University of Rouen – France: Promising DYRK1A inhibitor synthesized by late-stage C-H Arylation (right)
Birgit Gaiser, University of Copenhagen, Denmark: Targeting Metastable Binding Sites with Bitopic Ligands – A New Concept in GPCR Medicinal Chemistry (left)

Exhibitors at the GP2A-JFB2018 meeting :

Sponsors of the GP2A-JFB2018 meeting :

This year’s conference, GP2A-JFB 2018, organised by members from the Universities of Caen and Rouen will take place between 13th and 15th June at Asnelles sur Mer (Normandie).

Final program schedule is available HERE !!

Prizes will be given during the congress.
– 2 Best Poster Awards sponsored by ManRos Therapeutics
– 1 Best “PhD short communication” Award sponsored by MDPI
– 1 Best “Young researcher communication” Award sponsored by MDPI

As a joint meeting with the 32nd Journées Franco-Belges de Pharmacochimie, the 26th Annual GP2A Medicinal Chemistry Conference will provide a unique opportunity to engage with a wide group of European Chemists.

The “Journées Franco-Belges de Pharmacochimie” (JFB) is a widely recognized annual meeting on Medicinal Chemistry. This two-day symposium, whose first edition was held in 1986, aims to promote exchanges between medicinal chemists, mainly from France and Belgium. It is renowned for the advanced science presented, conviviality, and outstanding opportunities for senior and young scientists to exchange knowledge. An important part of the scientific program, besides plenary lectures given by internationally recognized scientists, is usually devoted to open lectures giving the opportunity for young scientists to present their research. The themes discussed during the meeting are those generally encountered by medicinal chemists: organic synthesis, bioinformatics and computer-aided drug design, pharmacological tests and molecular biology.

Registration fees

# Including 2 nights (Wednesday + Thursday) + 2 breakfasts (Thursday + Friday) + 3 lunches (Wednesday + Thursday + Friday) + 1 dinner (Wednesday) + 1 gala dinner (Thursday)

Academic: €300

PhD student: €200

Post-doctoral researcher: €200

Industrial: €350

# extra night (Tuesday) + 1 dinner (Tuesday) + 1 breakfast (Wednesday)

Academic: €365

PhD student: €265

Post-doctoral researcher: €265

Industrial: €450

Deadline for registration: 30th April 2018

Start of registration and abstract submission: 1st February 2018

PLEASE REGISTER HERE !!

Postdoctoral researchers and young Lecturers will be able to present their work as poster or as oral presentation (15 minutes + questions). Some abstracts will be selected by the Scientific Committee for oral presentation, the others will be presented as posters.

PhD students will be able to present their work as posters. Some abstracts will be selected for additional flash oral presentation (5 minutes w/o question).

PLEASE SUBMIT YOUR ABSTRACT HERE !! (abstract template)

For the venue to the site of congress, a shuttle will be available for free from Caen to Annelles sur Mer. More details will follow.

Most of the accommodation included in the registration are twin rooms. For single room booking, please contact the local organising committee.

Dr Louisa Barré, CEA, University of Caen, France

Rational development for a PET radiopharmaceutical probe

Dr Tatiana Besset, University of Rouen, France

Combining organofluorine chemistry and C-H activation: New tools to fluorinated molecules

Prof. Maria Laura Bolognesi, University of Bologna, Italy

Can theranostic small molecule combat neurodegenerative diseases?

Prof. Pascal Bonnet, University of Orléans, France

In silico Fragment-Based Design of Kinase inhibitors

Dr Thomas Cailly, University of Caen, France

Radio-iodination using a C-H activation approach

Prof. Raphaël Frédérick, University of Louvain, Belgium

Disrupting the metabolic adaptation of cancer cells with small molecules as a promising anticancer strategy

Dr Corinne Fruit, University of Rouen, France

Late-stage C-H arylation of thiazolo[5,4-f]quinazolin-9(8H)-one backbone: Synthesis of an array of potential kinase inhibitors

Prof. A. Ganesan, University of East Anglia, Norwich, United Kingdom

Targeting epigenetic erasers for drug discovery

Dr Cédric Logé, University of Nantes, France

New azole antifungals with fused pyrimidinone and triazinone derivatives

Dr Shailesh Mistry, University of Nottingham, United Kingdom

Molecular interrogation of multiple signalling states of the Beta-1 adrenoceptor

Dr Niamh O’Boyle, University of Dublin, Ireland

New anti-cancer small molecules

Prof. Maria-João R. P. Queiroz, University of Minho, Portugal

Synthesis of new di(hetero)arylamines derivatives of thieno[3,2-b]pyridines and evaluation of their neuroprotective activity on transgenic Caenorhabditis elegans -for Machado Joseph disease- as a model of study and toxicity

Prof. Anne-Sophie Voisin-Chiret, University of Caen, France

Pyridoclax and its derivatives directly inhibit Mcl-1 and exert potent antitumor effects on ovarian cancers in vitro and in vivo

Prof. Johan Van der Eycken, Ghent University, Belgium

Total synthesis and biological evaluation of Pelofen, a simplified analogue of Peloruside A with microtubule-stabilizing activity

 

CVs in brief…

Dr Louisa Barré
CEA, University of Caen, France
Head of the research team « Développements Méthodologiques en Tomographie par Emission de Positons » located at Caen on the imaging platform Cyceron. She has an expertise in – Radiochemistry using short-lived radionuclide (carbon-11, fluor-18, gallium-68) for PET imaging- innovative approaches – The development and evaluation in vivo of PET radiopharmaceuticals for diagnosis. She is involved in the “think tank” in the future of radiopharmaceutical compounds held under the auspices of “Health-related Technologies” piloted by Aviesan and France Life Imaging and in the “Club des radiopharmaceutiques. Its research is mainly focused on PET radiopharmaceutical for oncology.
Dr Tatiana Besset
University of Rouen, France
Dr Tatiana Besset obtained, in 2009, her PhD thesis in organic chemistry in the group of Dr A. E. Greene (University of Grenoble, France). After a first postdoctoral fellow in the group of Prof. F. Glorius (WWU Münster, Germany) and a second one in the group of Prof. J. N. H. Reek (University of Amsterdam, Netherlands), she is working, since 2012, as a CNRS Associate Researcher in the “Fluorinated Biomolecules Synthesis” team (headed by Prof. X. Pannecoucke, UMR 6014, Rouen, France). Her research focuses on the transition metal-catalyzed C–H activation and the development of new strategies for the synthesis of fluorinated building blocks.
Prof. Maria Laura Bolognesi
University of Bologna, Italy
Maria Laura Bolognesi is Professor of Medicinal Chemistry at the University of Bologna and an Associate Editor of Journal of Medicinal Chemistry. Her research interest are in the field of the design, synthesis, and pharmacological investigation of small molecules for neurodegenerative and neglected tropical diseases. She has a track record of 150 publications in high-ranked scientific journals, including patents and patent applications, and more than 60 invited talks worldwide. She was awarded a Distinguished Visiting Professor Fellowship at the Complutense University of Madrid in 2009 and a PVE Fellowship at the University of Brasilia (2014-2017).
Prof. Pascal Bonnet
University of Orléans, France
In 2012, Pascal Bonnet joined the Institute of Organic and Analytical Chemistry (ICOA) from the University of Orléans as full professor. Since then, he is leading the group of Structural Bioinformatics and Chemoinformatics, which develops and integrates novel computational methods for drug discovery. His research interests also focus on the development of an integrative in silico platform for kinase research. Since 2016, he is director of the ICOA. After completing his PhD in 2001 at the University of Orléans (France) and the University of Barcelona (Spain), he moved to a postdoctoral position at the University of Manchester, UK. As a scientist, he joined Janssen-Cilag in France and then Janssen-Pharmaceutica in Belgium in 2003.  He was involved in several drug discovery projects mainly in the oncology therapeutic area. Promoted Principal Scientist in 2010, he was leading the Kinase Platform at Janssen. He contributed to the design of a clinical drug candidate, erdafitinib, a kinase inhibitor discovered by FBDD currently in Phase II clinical trials.
Dr Thomas Cailly
University of Caen, France
Dr Thomas Cailly obtained is PhD from the University of Caen (2006) under the supervision of Pr. S. Rault. In 2006, he was appointed teaching and research assistant at the University of Caen and in 2007 research engineer. In 2008, he joined the group of Pr. M. Begtrup at the University of Copenhagen as a post-doctoral fellow. In 2009, he was appointed maître de conférences in bio-inorganic chemistry at the University of Caen and in 2014 joined the group of Pr. V. Gouverneur in Oxford for one year as a visiting scientist. His current research interests in the Centre d’Etudes et de Recherche sur le Médicament de Normandie (CERMN) include: medicinal chemistry applied to diagnostic tools, radio-iodination methodologies and C-H activation processes.
Prof. Raphaël Frédérick
University of Louvain, Belgium

Professor of Medicinal Chemistry, Louvain Drug Research Institute (LDRI), Medicinal Chemistry Research group, Université Catholique de Louvain (UCL), Bruxelles, Belgium

2015 – Louvain Drug Research Institute (UCL) – Vice-President

Main interests: medicinal chemistry in the broad sense, with a particular emphasis on rational computer-aided drug design and fragment-based drug discovery approaches. Targets mainly related to the field of anticancer immunotherapy and cancer metabolism

Dr Corinne Fruit
University of Rouen, France
Corinne Fruit received her Ph.D. degree from the University of Rouen in 2001. She undertook postdoctoral studies at the University of Ottawa with Pr Alex Fallis, working on the synthesis of new heteroarenes as kinase inhibitors, following by 2 years at the University of Geneva with Pr Paul Müller, dealing with rhodium catalyzed asymmetric transfer of nitrenes. In 2005, She joined the COBRA laboratory in Rouen as “Maître de Conférences”. Her current research area focuses on the development of new strategies for incorporating structural diversity into complex nitrogen containing heterocycles as valuable scaffolds for kinase inhibition.
Prof. A. Ganesan
University of East Anglia, Norwich,
United Kingdom

B.Sc. in Chemistry and Microbiology, National University of Singapore. Ph.D. in Chemistry, University of California-Berkeley. Postdoc in Chemistry, Harvard University. Academic positions at the Institute of Molecular and Cell Biology, Singapore and the University of Southampton, UK before present position at UEA.

Interests in chemical biology and medicinal chemistry, particularly epigenetics and natural products. Chair of the EU network COST Action Epigenetic Chemical Biology. Co-founder of the drug discovery company Karus Therapeutics.

Dr Cédric Logé
University of Nantes, France
Dr Cédric Logé is in charge of molecular modeling in the Department of Medicinal Chemistry of IICIMED-EA1155 (Nantes). He studied Organic Chemistry at the University of Lille 1 and did a PhD in Medicinal Chemistry at the University of Lille 2 under the supervision of Prof. Daniel Lesieur. After a postdoctoral fellow in molecular modeling with Prof. Philippe Chavatte, he joined the Faculty of Pharmacy of Nantes as an assistant professor in the Group of Pr. Robert, then Pr. Le Pape (IICIMED EA1155). His current research focus is in the area of invasive fungal infections with the goal of designing novel antifungal agents aided by molecular modeling tools.
Dr Shailesh Mistry
University of Nottingham,
United Kingdom
Dr Shailesh Mistry obtained his MPharm (Hons) degree (2003) and PhD (2009) from the School of Pharmacy, University of Nottingham. His PhD work (with Prof. Barrie Kellam/Prof. Steve Hill) focused on the development of highly selective ligands for the Beta-1 adrenoceptor and formed the basis of a Wellcome Trust Seeding Drug Discovery project, on which he completed his first postdoctoral position, and which culminated in the development of highly selective pre-clinical candidate compounds. Subsequently, he undertook a senior postdoctoral position in the group of Prof. Peter Scammells at the Monash Institute of Pharmaceutical Sciences (Melbourne, Australia), with a primary focus on the development of small molecule allosteric modulators for a range of G Protein-Coupled Receptors (GPCRs). In 2014 he returned to Nottingham as an Assistant Professor in Medicinal Chemistry. Current research interests continue to focus on the medicinal chemistry and chemical biology of ligands targeting GPCRs
Dr Niamh O’Boyle
University of Dublin, Ireland
Dr. Niamh O’Boyle received her BSc(Pharm) and PhD degree from Trinity College Dublin, and subsequently was awarded a postdoctoral scholarship at University of Göteborg in Sweden to investigate the allergenic activity of epoxides and epoxy resins. Subsequently, she was awarded a Government of Ireland Postdoctoral Research Fellowship at the School of Biochemistry & Immunology, TCD, working on ‘Cancer, Tubulin and Free Radicals: New Therapy’. Following a period as assistant lecturer at the School of Chemical and Pharmaceutical Sciences at Dublin Institute of Technology, she was appointed as assistant professor at the School of Pharmacy & Pharmaceutical Sciences at Trinity College Dublin in 2017. Her research interests lie in the areas of improving patient outcomes by applying the principles of medicinal chemistry.
Prof. Maria-João R. P. Queiroz
University of Minho, Portugal
Maria‐João Queiroz first graduated in Pharmaceutical Sciences in the Univ. of Porto‐Portugal (1986) followed by a PhD in Organic Chemistry (1993) in the Univ. of Minho‐ Portugal and carried out postdoctoral studies in heterocyclic chemistry in the Univ. of Metz‐France (1994). She is Coordinator Researcher since June 2009 in the Department/Centre of Chemistry of the Univ. of Minho and has a wide range of research interests in heterocyclic and medicinal chemistry
Prof. Anne-Sophie Voisin-Chiret
University of Caen, France
Pharm.D. (2002); Ph.D. Caen (2005), University of Caen Normandie (France).
Lecturer in Medicinal Chemistry (2007) in the School of Pharmacy at the University of Caen.
Since September 2015, she has assumed the position of Prof. of Medicinal Chemistry. Her research interests include medicinal chemistry in the field of protein-protein interactions, in order to design oligo(het)aromatic foldamers that mimic the ability of proteins to fold into well-defined conformations, such as helices and β-sheets. Since 2012 she has been leading a research program dedicated to the development of foldamers of interest in the treatment of ovarian cancers and neurodegenerative diseases.
Prof. Johan Van der Eycken
Ghent University, Belgium

Johan Van der Eycken (PhD from Ghent University [1986]; postdoctoral stay at Bergische Universität, Wuppertal, Germany [1986]) is Professor in Organic Chemistry and Head of the Laboratory for Organic and Bioorganic Synthesis (LOBOS) at Ghent Universtity (UGent), Belgium.

His main research topics are design of novel chiral ligands for asymmetric transition metal catalysis, total synthesis of complex biologically active compounds (e.g. Lipid II analogues, macrocyclic antibiotics, e.g. Peloruside A), and solid phase synthesis of peptidomimetics and small organic molecules as privileged scaffolds for drug discovery.

Best Early career researchers presentation

Dr Amit Nathubhai, University of Bath – UK: Dual-site-binding tankyrase inhibitors as potential agents towards the treatment of colorectal cancer and type-2 diabetes

Best Flash presentation

Isabelle Lengers, Westfälische Wilhelms-Universität Münster – Germany: Human Hyal-1 – from in silico pharmacophore modeling to in vitro inhibitor screening

Best Posters

Alexia Ville, University of Angers – France: Semisynthetics pathways starting from δ-garcinoic acid towards anti-inflammatory tocotrienols isolated from New-Caledonian endemic plants

Michael B. C. Kenny, University of Bath – UK: Synthesis and evaluation of a range of seco-amino-CBIs as highly cytotoxic DNA alkylating agents

Poster sessions and drinks reception

Conference dinner at Victoria Gallery & Museum of Liverpool

The GP2A 2017 conference, organized by Dr Susan E. Matthews, Prof. Michael D. Threadgill and Dr Francesca Giuntini, took place in Liverpool John Moores University (UK):

Plenary lectures

Prof. Olivier Duval
University of Angers (F)
Dr Lorenzo Caggiano
University of Bath (UK)
Professor Satyajit Sarker
University of Liverpool (UK)
Dr Celine Cano
University of Newcastle (UK)
Prof. Maria-João R. P. Queiroz
University of Minho (P)
Prof. Pascal Marchand
University of Nantes (F)
Prof. Paul O’Neill
University of Liverpool (UK)
Dr Jean-Jacques Helesbeux
University of Angers (F)
 
Prof. Andrew Westwell
University of Cardiff (W)
Prof. Sophie Tomasi
University of Rennes 1 (F)
Dr Gerard McGlacken
University of Cork (IRL)
Prof. Joachim Jose
Universität Münster (G)

Early career researchers’ showcases

Dr Stéphane Gérard
University of Reims Champagne-Ardenne (F)
Dr Tobias Gruber
University of Lincoln (UK)
Dr Nicolas Primas
University Aix-Marseille (F)
Dr Gerta Cami-Kobeci
University of Bath (UK)
Victor Babin
University of Caen Normandie (F)
Dr Amit Nathubhai
University of Bath (UK)
Dr Goreti Ribeiro Morais
University of Bradford (UK)

Flash presentations of posters (doctoral students)

Clara E. Charleton
Trinity College Dublin (IRL)
Dartagnan D. S. P. Ferreira
University of Nantes (F) and University of Pernambuco (BRE)
Benjamin Guieu
University of Rennes 1 (F)
Bérénice Hatat
University of Caen Normandie (F)
Isabelle Lengers
Westfälische Wilhelms-Universität Münster (G)
Husain A. Naqi
University of Bath (UK)
 
Rebecca I. Thomson
University of Reading (UK)

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